Vasoregulatory function of the heme-heme oxygenase-carbon monoxide system
نویسندگان
چکیده
منابع مشابه
What role does the heme-- heme oxygenase--carbon monoxide system play in vasoregulation?
IN 1990, WE NOTED TO OUR SURPRISE that when carbon monoxide (CO) was bubbled into a tissue bath containing a rabbit aortic strip precontracted with phenylephrine, the vascular tissue relaxed (7). Perusal of the literature revealed that other investigators had reported on the vasorelaxant effect of CO in vascular smooth muscle preparations from a variety of animal species (7). At this time, the ...
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(cGMP). Like NO , CO can also activate guanylate cyclase to cause vasodilation [5] ; however, previous studies have indicated that other mechanisms may contribute to the effects of CO on hepatic tone [6] . In their study [4] , the authors found some potentially novel mechanisms by which HO-1 mediates hepatic tone that appear independent of cGMP and, at least in part, independent of CO . The aut...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2001
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(01)02071-4